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Protein NMR Senior Scientist - Beatson Institute

The Drug Discovery Unit at the CRUK Beatson Institute in Glasgow, is a Cancer Research UK funded team of highly experienced scientists engaged in discovering and developing cancer drug treatments of the future. The aim of the Unit is to work closely with local cancer experts to maximise the opportunity to develop new and innovative therapies that strike at the core of cancer pathology. Using state of the art screening, advanced structural biology, industry standard medicinal chemistry and complex biological modelling systems, the Drug Discovery team at the Beatson is tackling some of the most challenging targets in cancer biology today.

We are looking for a talented and motivated Protein NMR scientist who will take a central role in our structural sciences team. The ideal candidate should have extensive hands-on experience with high-resolution protein NMR spectroscopy, including interpretation and experimental set-up. The DDU is equipped with state-of-the-art NMR spectrometers (Bruker NEO400 and NEO600 with a CryoProbe). In addition, we are also members of a consortium which enables us to access the recently upgraded 800MHz spectrometer at Edinburgh University.

Playing an influential role in our drug discovery projects, you will work collaboratively with biophysicists, protein scientists, crystallographers, biologists and chemists at the Beatson and wider CRUK network to help formulate innovative and forward thinking approaches towards tackling exciting and challenging drug target classes.

The role requires you to develop biophysical assays to characterise protein ligand interactions, applying these to medicinal chemistry-driven projects from fragment-based hit identification through to lead optimisation. The quality data that you produce will be critical, helping teams form an understanding of both the mechanism of action of our molecules and the target biology.

In addition, you will contribute to the development of the biophysics discipline by identifying and driving improvements and innovations that advance drug discovery projects.

Skills & Experience:

  • PhD in Biochemistry or a related discipline with strong skills in protein NMR assignment.

  • Experience of NMR for measuring protein-ligand interactions and solution structures is highly desirable.

  • Small molecule NMR for structure and purity determination is required.

  • Experience of additional biophysical techniques (e.g. ITC & SPR) along with a solid understanding of protein science and enzymology is also desirable.

  • Experience of working in a drug discovery environment where structural and biophysical studies are central to project progression would be an advantage.

  • Excellent communication and collaborative approach, including experience of working as part of multidisciplinary team.

 

In return, we offer an inspiring, supportive and multi-disciplinary environment in a state-of-the-art, purpose built laboratory in which to further enhance your skills and knowledge of structural sciences, biophysics, cancer biology and drug discovery; providing you the opportunity to make a real difference to the lives of cancer patients.

Closing date: 12th December 2020

Informal enquiries are welcome and should be addressed to Dr Justin Bower (Joint Head of Beatson Drug Discovery Unit).

To apply, click here.